Tetrodotoxin
نویسندگان
چکیده
In this Quick Guide, Lorentz et al. discuss the function of tetrodotoxin and its distribution in the animal kingdom.
منابع مشابه
Epinephrine prevents muscle blood flow increases after perineural injection of tetrodotoxin.
BACKGROUND The local anesthetic properties of tetrodotoxin, a potent naturally occurring sodium channel blocker, have been recently reexamined. It was found that sciatic nerve block duration could be greatly increased and systemic toxicity greatly decreased if epinephrine was injected with tetrodotoxin. The mechanism that underlies epinephrine-mediated prolongation of tetrodotoxin nerve blocks ...
متن کاملSynthesis and mode of action on axonal membranes of photoactivable derivatives of tetrodotoxin.
Two photoactivable derivatives of tetrodotoxin have been synthesized. Electrophysiological experiments on crab giant axons and competitive binding with [3H]-tetrodotoxin for the tetrodotoxin receptor indicate that they are only 4.5 to 7.5 times less active than tetrodotoxin itself. These compounds give a reversible block of the sodium channel in the dark but after ultraviolet irradiation they p...
متن کاملSpatial gradient in TTX sensitivity of axons at the crayfish opener neuromuscular junction.
At the crayfish opener neuromuscular junction, axons branch repeatedly before synapsing onto muscle fibers as varicosities. Excitability of these axons was examined with two-electrode current clamp before and after partial block of Na(+) channels with 1 nM tetrodotoxin. 4-Aminopyridine (200 μM) was added to homogenize nonuniformity in K(+) channel density. The impact of tetrodotoxin was evaluat...
متن کاملProduction of tetrodotoxin in puffer fish embryos.
It has been accepted that puffer fish accumulates tetrodotoxin through the food chain. This indicates that tetrodotoxin in puffer fish is exogenous. The present study, however, describes an endogenous origin of tetrodotoxin in puffer fish. For this purpose, the ovulated oocytes from puffer fish Fugu niphobles were artificially fertilized and cultivated. The toxin levels of embryos increased gra...
متن کاملNa+ channels with high and low affinity tetrodotoxin binding sites in the mammalian skeletal muscle cell. Difference in functional properties and sequential appearance during rat skeletal myogenesis.
High and low affinity binding sites for tetrodotoxin have been found in rat skeletal muscle cells in vitro using a radiolabeled tetrodotoxin derivative and 22Na+ flux studies. High affinity binding sites for tetrodotoxin (KD(tetrodotoxin) = 1.6 nM) cannot be detected at the myoblast stage. They appear and increase in density as myoblasts fuse into myotubes to reach a maximum binding capacity of...
متن کاملEvaluation of the possible proapoptotic effect on Tetrodotoxin on Ehrlich Ascites Carcinoma Cells (EAC) using P53 & Caspase 3 immunohistochemistry in mice's liver
It is becoming obvious that all cancers have a defective p53 pathway, either through TP53 mutation or deregulation of the tumor suppressor function of the wild type TP53. In this study we examined the expression of P53 and Caspase 3 in transperitoneally injected Ehrlich Ascites carcinoma cells (EAC) treated with Tetrodotoxin in the liver of adult mice in order to evaluate the possible pro apopt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 26 شماره
صفحات -
تاریخ انتشار 2016